Hepatocellular adenoma among adult survivors of childhood and young adult cancer. Issue 4 (26th October 2016)

• Record Type: Journal Article
• Authors: Tonorezos, Emily S.; Barnea, Dana; Abou‐Alfa, Ghassan K.; Bromberg, Jacqueline; D'Angelica, Michael; Sklar, Charles A.; Shia, Jinru; Oeffinger, Kevin C.
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 4(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-10-26
• Subjects: childhood cancer -- hepatocellular adenoma -- hepatoma -- survivor; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26294
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1, 000, 000. We identified 12 cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N = 4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All 11 females had prior estrogen therapy; the male case was hypogonadal. This report suggests childhood and young adult cancer survivors may be at increased risk for HCA, but further investigation is needed.