Identification and analytical characterization of four synthetic cathinone derivatives iso‐4‐BMC, β‐TH‐naphyrone, mexedrone, and 4‐MDMC. Issue 2 (28th June 2016) - Qian, Zhenhua
Abstract : New psychoactive substances (NPS) have gained much popularity on the global market over the last number of years. The synthetic cathinone family is one of the most prominent groups and this paper reports on the analytical properties of four synthetic cathinone derivatives: (1 ) 1‐(4‐bromophenyl)‐1‐(methylamino)propan‐2‐one (iso‐4‐BMC or iso‐brephedrone), (2 ) 2‐(pyrrolidin‐1‐yl)‐1‐(5, 6, 7, 8‐tetrahydronaphthalen‐2‐yl)pentan‐1‐one ( β ‐TH‐naphyrone), (3 ) 3‐methoxy‐2‐(methylamino)‐1‐(4‐methylphenyl)propan‐1‐one (mexedrone), and (4 ) 2‐(dimethylamino)‐1‐(4‐methylphenyl)propan‐1‐one (4‐MDMC). These identifications were based on liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry (LC‐QTOF‐MS), gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance (NMR) spectroscopy. To our knowledge, no chemical or pharmacological data about compounds1–3 have appeared until now, making this the first report on these compounds. The Raman and GC‐MS data of4 have been reported, but this study added the LC‐MS and NMR data for additional characterization. Copyright © 2016 John Wiley & Sons, Ltd. Abstract : Four synthetic cathinone derivatives, iso‐4‐BMC, β ‐TH‐naphyrone, mexedrone, and 4‐MDMC were identified using LC‐QTOF‐MS, GC‐MS, and NMR.