Triply phenoxo bridged Eu(iii) and Sm(iii) complexes with 2, 6-diformyl-4-methylphenol-di(benzoylhydrazone): structure, spectra and biological study in human cell lines. (28th November 2014)

• Record Type: Journal Article
• Authors: Das, Kuheli; Nandi, Soumendra; Mondal, Sudipa; Askun, Tulin; Cantürk, Zerrin; Celikboyun, Pinar; Massera, Chiara; Garribba, Eugenio; Datta, Amitabha; Sinha, Chittaranjan; Akitsu, Takashiro
• Is Part Of: New journal of chemistry. Volume 39:Number 2(2015:Feb.)
• Page Start: 1101
• Page End: 1114
• Publication Date: 2014-11-28
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c4nj01464b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Two dinuclear lanthanide(iii ) complexes, [M2 (HL)3 ] (M = Sm(iii ) (1 ), Eu(iii ) (2 ); H3 L, 2, 6-diformyl-4-methylphenol-di(benzoylhydrazone)) were generated with good yield and characterised systematically. Abstract : Two dinuclear lanthanide(iii ) complexes, [M2 (HL)3 ] (M = Sm(iii ) (1 ), Eu(iii ) (2 ); H3 L, 2, 6-diformyl-4-methylphenol-di(benzoylhydrazone)) were generated with good yield and characterised systematically. The single crystal X-ray structure determination of [Eu2 (HL)3 ] (2 ) confirmed the tricapped trigonal prismatic geometry of the N3 O6 coordination environment around europium. Indeed, Eu(1 ) and Eu(2 ) are bridged by phenolato-O belonging to the p -cresol ring, by deprotonated 'enol' groups from the benzoyl hydrazide part and by the imine-N centres. A temperature dependent magnetic study suggested that anti-ferromagnetic coupling occurs between the two Eu(iii ) ions and the magnetic moment was found to vary from 0.48 B.M. at 5 K to 3.03 B.M. at 300 K. Electron paramagnetic resonance spectroscopy confirmed that anti-ferromagnetic coupling occurs between the atoms of Eu(iii ) and Sm(iii ). Both the complexes show emission in the visible range. The ligand, H3 L and the complexes exhibit anti-mycobacterial activity against M. tuberculosis H37Rv (ATCC 27294) and M. tuberculosis H37Ra (ATCC 25177) strains. The molecular docking of H3 L with the enoyl acyl carrier protein reductase of M. tuberculosis H37Rv (PDB ID: ; Web:4U0K ) was examined and the best docked pose of H3 L was shown to have one hydrogen bond with Thr196 (2.03 Å).