Adolescent vulnerability to cardiovascular consequences of chronic emotional stress: Review and perspectives for future research. (March 2017)

• Record Type: Journal Article
• Authors: Crestani, Carlos C.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 74:Part B(2017)
• Page Start: 466
• Page End: 475
• Publication Date: 2017-03
• Subjects: Social stress -- Psychological stress -- Ontogeny -- Adolescence -- Cardiovascular function -- Autonomic activity -- Arterial pressure -- Heart rate -- Baroreflex -- HPA axis -- Rodents; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2016.03.027
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Adolescence is proposed as an ontogenic period of vulnerability to stress. Cardiovascular vulnerability during adolescence is dependent of stress paradigm. Stress during adolescence minimally affects cardiovascular function in adulthood. Abstract: Emotional stress has been recognized as a modifiable risk factor for cardiovascular diseases. Adolescence has been proposed as a developmental period of vulnerability to stress. This idea has been mainly supported by experimental research in animals demonstrating a higher impact of chronic emotional stress in adolescents compared with adults. Adolescent vulnerability is also based on evidence that stress during this developmental period affects development, so that enduring changes are found in adult animals that experienced stress during adolescence. The purpose of the present review is to discuss experimental research in rodent models that investigated the impact of long-term exposure to stressful events during adolescence on cardiovascular function. The development of cardiovascular function and autonomic activity in rodents is initially reviewed. Then, a discussion of an adolescent vulnerability to cardiovascular effects of chronic stress is presented. From the reviewed literature, perspective for future research is proposed to better elucidate adolescent vulnerability to cardiovascular complications evoked by chronic emotional stress.