Multitracer Molecular Imaging of Paget Disease Targeting Bone Remodeling, Fatty Acid Metabolism, and PSMA Expression on PET/CT. (December 2016)

• Record Type: Journal Article
• Authors: Derlin, Thorsten; Weiberg, Desiree; Sohns, Jan M.
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 12(2016)
• Publication Date: 2016-12
• Subjects: PSMA -- morbus paget -- prostate cancer -- 18F-fluoride -- 11C-acetate -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001413
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Paget disease is a chronic disorder resulting in enlarged and misshapen bones, and is caused by disorganized bone remodeling. We present the case of an 85-year-old man with prostatic adenocarcinoma and known Paget disease of the right iliac bone who underwent 68 Ga–prostate-specific membrane antigen ligand, 11 C-acetate, and 18 F-fluoride PET/CT for restaging of cancer. On all PET scans, increased tracer accumulation was observed in Paget disease of bone. Besides that Paget disease may mimic metastases on PET/CT using various radiotracers, including 68 Ga–prostate-specific membrane antigen ligands and 11 C-acetate, this case highlights the potential of multiparametric disease characterization on PET.