Nifekalant Hydrochloride and Amiodarone Hydrochloride Result in Similar Improvements for 24-Hour Survival in Cardiopulmonary Arrest Patients: The SOS-KANTO 2012 Study. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Amino, Mari; Inokuchi, Sadaki; Nagao, Ken; Nakagawa, Yoshihide; Yoshioka, Koichiro; Ikari, Yuji; Funakoshi, Hiraku; Hayakawa, Katsura; Matsuzaki, Masakazu; Sakurai, Atsushi; Tahara, Yoshio; Yonemoto, Naohiro; Yaguchi, Arino; Morimura, Naoto
• Is Part Of: Journal of cardiovascular pharmacology. Volume 66:Issue 6(2015)
• Publication Date: 2015-12
• Subjects: cardiopulmonary resuscitation -- shock-resistant ventricular fibrillation -- pharmacological defibrillation -- nifekalant hydrochloride -- amiodarone hydrochloride; Cardiovascular Diseases -- drug therapy -- Periodicals; Cardiovascular System -- drug effects -- Periodicals; Cardiovascular pharmacology -- Periodicals; Cardiovascular agents -- Periodicals; Cardiovascular agents; Cardiovascular pharmacology; Periodicals; 615.7105
• DOI: 10.1097/FJC.0000000000000310
• Languages: English
• ISSNs: 0160-2446

Abstract

Abstract : Background: Amiodarone (AMD), nifekalant (NIF), and lidocaine (LID) hydrochlorides are widely used for ventricular tachycardia/fibrillation (VT/VF). This study retrospectively investigated the NIF potency and the differential effects of 2 initial AMD doses (⩽150 mg or 300 mg) in the Japanese SOS-KANTO 2012 study population. Methods and Results: From 16, 164 out-of-hospital cardiac arrest cases, 500 adult patients using a single antiarrhythmic drug for shock-resistant VT/VF were enrolled and categorized into 4 groups (73 LID, 47 NIF, 173 AMD-⩽150, and 207 AMD-300). Multivariate analyses evaluated the outcomes of NIF, AMD-⩽150, or AMD-300 groups versus LID group. Odds ratios (ORs) for survival to admission were 3.21 [95% confidence interval (CI): 1.38–7.44, P < 0.01] in NIF and 3.09 (95% CI: 1.55–6.16, P < 0.01) in AMD-⩽150 groups and significantly higher than those of the LID group. However, the OR was 1.78 (95% CI: 0.90–3.51, P = 0.10) in AMD-300 group and was not significant than LID group. ORs for 24-hour survival were 6.68 in NIF, 4.86 in AMD-⩽150, and 2.97 in AMD-300, being significantly higher in these groups. Conclusions: NIF and AMD result in similar improvements for 24-hour survival in cardiopulmonary arrest patients, and this suggest the necessity of a randomized control study.