BrachyView: Combining LDR seed positions with transrectal ultrasound imaging in a prostate gel phantom. (February 2017)
- Record Type:
- Journal Article
- Title:
- BrachyView: Combining LDR seed positions with transrectal ultrasound imaging in a prostate gel phantom. (February 2017)
- Main Title:
- BrachyView: Combining LDR seed positions with transrectal ultrasound imaging in a prostate gel phantom
- Authors:
- Alnaghy, S.
Cutajar, D.L.
Bucci, J.A.
Enari, K.
Safavi-Naeini, M.
Favoino, M.
Tartaglia, M.
Carriero, F.
Jakubek, J.
Pospisil, S.
Lerch, M.
Rosenfeld, A.B.
Petasecca, M. - Abstract:
- Highlights: BrachyView is an in-body gamma camera for seed imaging in prostate brachytherapy. Thirty I-125 seeds were reconstructed in a tissue equivalent prostate gel phantom. BrachyView-TRUS image fusion using a mechanical co-registration method is performed. It was observed that 75% of seed positions were reconstructed within 1 mm of CT. Abstract: Purpose: BrachyView is a novel in-body imaging system which aims to provide LDR brachytherapy seeds position reconstruction within the prostate in real-time. The first prototype is presented in this study: the probe consists of a gamma camera featuring three single cone pinhole collimators embedded in a tungsten tube, above three, high resolution pixelated detectors (Timepix). Methods: The prostate was imaged with a TRUS system using a sagittal crystal with a 2.5 mm slice thickness. Eleven needles containing a total of thirty 0.508 U 125 I seeds were implanted under ultrasound guidance. A CT scan was used to localise the seed positions, as well as provide a reference when performing the image co-registration between the BrachyView coordinate system and the TRUS coordinate system. An in-house visualisation software interface was developed to provide a quantitative 3D reconstructed prostate based on the TRUS images and co-registered with the LDR seeds in situ. A rigid body image registration was performed between the BrachyView and TRUS systems, with the BrachyView and CT-derived source locations compared. Results: TheHighlights: BrachyView is an in-body gamma camera for seed imaging in prostate brachytherapy. Thirty I-125 seeds were reconstructed in a tissue equivalent prostate gel phantom. BrachyView-TRUS image fusion using a mechanical co-registration method is performed. It was observed that 75% of seed positions were reconstructed within 1 mm of CT. Abstract: Purpose: BrachyView is a novel in-body imaging system which aims to provide LDR brachytherapy seeds position reconstruction within the prostate in real-time. The first prototype is presented in this study: the probe consists of a gamma camera featuring three single cone pinhole collimators embedded in a tungsten tube, above three, high resolution pixelated detectors (Timepix). Methods: The prostate was imaged with a TRUS system using a sagittal crystal with a 2.5 mm slice thickness. Eleven needles containing a total of thirty 0.508 U 125 I seeds were implanted under ultrasound guidance. A CT scan was used to localise the seed positions, as well as provide a reference when performing the image co-registration between the BrachyView coordinate system and the TRUS coordinate system. An in-house visualisation software interface was developed to provide a quantitative 3D reconstructed prostate based on the TRUS images and co-registered with the LDR seeds in situ. A rigid body image registration was performed between the BrachyView and TRUS systems, with the BrachyView and CT-derived source locations compared. Results: The reconstructed seed positions determined by the BrachyView probe showed a maximum discrepancy of 1.78 mm, with 75% of the seeds reconstructed within 1 mm of their nominal location. An accurate co-registration between the BrachyView and TRUS coordinate system was established. Conclusions: The BrachyView system has shown its ability to reconstruct all implanted LDR seeds within a tissue equivalent prostate gel phantom, providing both anatomical and seed position information in a single interface. … (more)
- Is Part Of:
- Physica medica. Volume 34(2017)
- Journal:
- Physica medica
- Issue:
- Volume 34(2017)
- Issue Display:
- Volume 34, Issue 2017 (2017)
- Year:
- 2017
- Volume:
- 34
- Issue:
- 2017
- Issue Sort Value:
- 2017-0034-2017-0000
- Page Start:
- 55
- Page End:
- 64
- Publication Date:
- 2017-02
- Subjects:
- In-vivo dosimetry -- Brachytherapy -- Image fusion
Medical physics -- Periodicals
Biophysics -- Periodicals
Biophysics -- Periodicals
Imagerie médicale -- Périodiques
Radiothérapie -- Périodiques
Rayons X -- Sécurité -- Mesures -- Périodiques
Physique -- Périodiques
Médecine -- Périodiques
610.153 - Journal URLs:
- http://www.sciencedirect.com/science/journal/11201797 ↗
http://www.clinicalkey.com/dura/browse/journalIssue/11201797 ↗
http://www.clinicalkey.com.au/dura/browse/journalIssue/11201797 ↗
http://www.elsevier.com/journals ↗
http://www.physicamedica.com ↗ - DOI:
- 10.1016/j.ejmp.2017.01.012 ↗
- Languages:
- English
- ISSNs:
- 1120-1797
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6475.070000
British Library DSC - BLDSS-3PM
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