Csp3−H Activation without Chelation Assistance in an Iridium Pincer Complex Forming Cyclometallated Products. Issue 8 (16th January 2017)

• Record Type: Journal Article
• Authors: Ahlstrand, David A.; Polukeev, Alexey V.; Marcos, Rocío; Ahlquist, Mårten S. G.; Wendt, Ola F.
• Is Part Of: Chemistry. Volume 23:Issue 8(2017)
• Page Start: 1748
• Page End: 1751
• Publication Date: 2017-01-16
• Subjects: cyclometallation -- density functional calculations -- iridium -- pincer complexes -- undirected C−H activation; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201604469
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Cyclometallation of 8‐methylquinoline and 2‐(dimethylamino)‐pyridine in an iridium‐based pincer complex is described. The C−H activation of 2‐(dimethylamino)pyridine is not chelation assisted, which has not been described before for Csp 3 −H bonds in cyclometallation reactions. The mechanism of the cyclometallation of 2‐(dimethylamino)pyridine was studied by DFT calculations and kinetic measurements. Abstract : Help is not needed ! The C−H activation of 2‐(dimethylamino)pyridine is not chelation assisted, indicating that pre‐coordination may be less common in cyclometallation reactions than previously thought (see scheme).