Breakthrough fungemia due to Candida fermentati with fks1p mutation under micafungin treatment in a cord blood transplant recipient. Issue 1 (28th December 2016)

• Record Type: Journal Article
• Authors: Konuma, Takaaki; Takahashi, Shunsuke; Kiyuna, Tomohiko; Miharu, Yuta; Suzuki, Masato; Shibata, Hiroko; Kato, Seiko; Takahashi, Satoshi; Tojo, Arinobu
• Is Part Of: Transplant infectious disease. Volume 19:Issue 1(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-12-28
• Subjects: Candida fermentati -- candidemia -- echinocandin -- fks1 -- hematopoietic cell transplantation -- micafungin; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12634
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: The prophylactic use of antifungal drugs in allogeneic hematopoietic cell transplant recipients has revealed that the rate of non ‐albicans candidemia has increased. We herein report the case of a patient with adult T‐cell leukemia who developed candidemia due to Candida fermentati during micafungin treatment after cord blood transplantation. The isolate was identified on day 47 by sequencing of the internal transcribed spacer region of the ribosomal RNA gene. The sequencing of the hot spot region of fks1p of isolate revealed naturally occurring amino acid substitutions, which conferred reduced echinocandin susceptibility. This case highlights that breakthrough candidemia due to C. fermentati occurred in a patient receiving micafungin treatment.