Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection. Issue 109 (11th November 2016)

• Record Type: Journal Article
• Authors: Das, Gobind; Alrasheed, Salma; Coluccio, Maria Laura; Gentile, Francesco; Nicastri, Annalisa; Candeloro, Patrizio; Cuda, Giovanni; Perozziello, Gerardo; Di Fabrizio, Enzo
• Is Part Of: RSC advances. Volume 6:Issue 109(2016)
• Page Start: 107916
• Page End: 107923
• Publication Date: 2016-11-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra23301e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Self-similar chain based nanolens plasmonic devices were fabricated for detecting single point mutations. Abstract : Advancements in nanotechnology fabrication techniques allow the possibility to design and fabricate a device with a minimum gap (<10 nm) between the composing nanostructures in order to obtain better control over the creation and spatial definition of plasmonic hot-spots. The present study is intended to show the fabrication of nanolens and their application to single/few molecules detection. Theoretical simulations were performed on different designs of real structures, including comparison of rough and smooth surfaces. Various molecules (rhodamine 6G, benzenethiol and BRCA1/BRCT peptides) were examined in this regard. Single molecule detection was possible for synthetic peptides, with a possible application in early detection of diseases.