Inside Cover: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging (ChemBioChem 1/2017). (20th December 2016)

• Record Type: Journal Article
• Authors: Wong, Pamela T.; Tang, Shengzhuang; Cannon, Jayme; Mukherjee, Jhindan; Isham, Danielle; Gam, Kristina; Payne, Michael; Yanik, Sean A.; Baker, James R.; Choi, Seok Ki
• Is Part Of: Chembiochem. Volume 18:Number 1(2017)
• Page Start: 2
• Page End: 2
• Publication Date: 2016-12-20
• Subjects: antitumor agents -- caged compounds -- controlled release -- dual arm cage -- fluorescence reporter -- photolysis; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201600661
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The inside cover picture shows the concept of a new binary photocage that enables synchronous controlled release of two payloads linked to a single cage unit. This cage is based on photocleavable thioacetal ortho ‐nitrobenzaldehyde, and its utility is illustrated by cross‐tethering both an anticancer agent and a fluorescent reporter to the cage. Caging temporarily retains the drug in an inactive state and quenches reporter fluorescence. The extent of light‐controlled dual release is quantifiable by reporter fluorescence measured in situ. This strategy provides new possibilities for real‐time monitoring of drug or effector activation in cellular systems and at delivery sites. More information can be found in the full paper by P. T. Wong, S. K. Choi et al. onpage 126 in Issue 1, 2017 (DOI:10.1002/cbic.201600494 ).