Non–muscle‐invasive bladder cancer: Intravesical treatments beyond Bacille Calmette‐Guérin. Issue 3 (2nd November 2016)

• Record Type: Journal Article
• Authors: Packiam, Vignesh T.; Johnson, Scott C.; Steinberg, Gary D.
• Is Part Of: Cancer. Volume 123:Issue 3(2017)
• Page Start: 390
• Page End: 400
• Publication Date: 2016-11-02
• Subjects: bacille Calmette‐Guérin (BCG) -- bladder‐sparing -- chemotherapy -- immunotherapy -- intravesical -- non–muscle‐invasive bladder cancer -- urothelial neoplasms; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.30392
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : An unmet need exists for patients with high‐risk non–muscle‐invasive bladder cancer for whom bacille Calmette‐Guérin (BCG) has failed and who seek further bladder‐sparing approaches. This shortcoming poses difficult management dilemmas. This review explores previously investigated first‐line intravesical therapies and discusses emerging second‐line treatments for the heterogeneous group of patients for whom BCG has failed. The myriad of recently published and ongoing trials assessing novel salvage intravesical treatments offer promise to patients who both seek an effective cure and want to avoid radical surgery. However, these trials must carefully be contextualized by specific patient, tumor, and recurrence characteristics. As data continue to accumulate, there will potentially be a role for these agents as second‐line or even first‐line intravesical therapies. Cancer 2017;123:390–400. © 2016 American Cancer Society . Abstract : An unmet need continues to exist for patients with high‐risk non–muscle‐invasive bladder cancer for whom Bacille Calmette‐Guérin has failed and who seek further bladder‐sparing approaches. This review explores the role of emerging intravesical therapies.