Oral Chemoprevention With Acetyl Salicylic Acid, Vitamin D and Calcium Reduces the Risk of Tobacco Carcinogen-Induced Bladder Tumors in Mice. (1st August 2013)

• Record Type: Journal Article
• Authors: Pommergaard, H. C.; Burcharth, J.; Rosenberg, J.; Raskov, H.
• Is Part Of: Cancer investigation. Volume 31:Number 7(2013)
• Page Start: 490
• Page End: 493
• Publication Date: 2013-08-01
• Subjects: Chemoprevention -- Bladder cancer -- Experimental model -- Tobacco carcinogens -- Combination therapy; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2013.820316
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract : Bladder cancer is a common urological malignancy with high recurrence rate, which may be reduced by chemoprevention. The aim was to evaluate chemoprevention in a mouse model of tobacco carcinogen-induced bladder tumors. A total of 60 A/J mice were randomized to normal diet, diet with low calcium, and diet with chemoprevention (acetyl salicylic acid, 1-alpha 25(0H)2 -vitamin D3 and calcium). There were significantly fewer tumors (0 (0–0) vs. 0 (0–2), p = .045) and fewer animals with tumors (0/20 vs. 5/20, p = .045) in the chemoprevention group compared with controls. Thus, chemoprevention diet effectively reduced the tumor promoting effect of tobacco carcinogens in the mouse bladder.