Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma. Issue 2 (15th January 2017)

• Record Type: Journal Article
• Authors: Lu, Yen-Ta; Chen, Tien-Ling; Chang, Kuo-Song; Chang, Chia-Ming; Wei, Tsai-Yin; Liu, Jen-Wei; Hsiao, Chih-Ang; Shih, Tzenge-Lien
• Is Part Of: Bioorganic & medicinal chemistry. Volume 25:Issue 2(2017)
• Page Start: 789
• Page End: 794
• Publication Date: 2017-01-15
• Subjects: Benzazole -- B16F10 cells -- Melanoma -- MTS assay -- Naphthalimide -- Topoisomerase II; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2016.11.057
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds9 and10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.