Analyses of anticancer drugs by capillary electrophoresis: a review. (11th July 2013)

• Record Type: Journal Article
• Authors: Ali, Imran; Haque, Ashanul; Wani, Waseem A.; Saleem, Kishwar; Al Za'abi, Mohammed
• Other Names: Srinivas NR guestEditor.
• Is Part Of: Biomedical chromatography. Volume 27:Number 10(2013:Oct.)
• Page Start: 1296
• Page End: 1311
• Publication Date: 2013-07-11
• Subjects: capillary electrophoresis -- anticancer drugs -- biological samples -- future perspectives; Chromatographic analysis -- Periodicals; Biology -- Periodicals; Medicine -- Periodicals; Biology -- Periodicals; Chromatography -- methods -- Periodicals; Medicine -- Periodicals; 543.089
• DOI: 10.1002/bmc.2953
• Languages: English
• ISSNs: 0269-3879

Abstract

ABSTRACT: Capillary electrophoresis is a fast, inexpensive and low detection limit technique for the analysis of anticancer drugs. It has been used to analyze various anticancer drugs in biological samples, pharmaceutical preparations and environmental matrices. It has also been used to detect various cancer biomarkers in cancer patients. The present article describes the state‐of‐the art of capillary electrophoresis for the analyses of anticancer drugs. Various drugs discussed belong to several groups such as antimitotic agents, nucleoside analogs, antibiotics, topoisomerase inhibitors and DNA intercalating agents. In addition, efforts have also been made to discuss sample preparation, applications of capillary electrophoresis in genomic research, optimization and future perspectives. Copyright © 2013 John Wiley & Sons, Ltd.