In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET. (29th November 2016)

• Record Type: Journal Article
• Authors: Kikuchi, Akio; Okamura, Nobuyuki; Hasegawa, Takafumi; Harada, Ryuichi; Watanuki, Shoichi; Funaki, Yoshihito; Hiraoka, Kotaro; Baba, Toru; Sugeno, Naoto; Oshima, Ryuji; Yoshida, Shun; Kobayashi, Junpei; Ezura, Michinori; Kobayashi, Michiko; Tano, Ohito; Mugikura, Shunji; Iwata, Ren; Ishiki, Aiko; Furukawa, Katsutoshi; Arai, Hiroyuki; Furumoto, Shozo; Tashiro, Manabu; Yanai, Kazuhiko; Kudo, Yukitsuka; Takeda, Atsushi; Aoki, Masashi
• Is Part Of: Neurology. Volume 87:Number 22(2016)
• Page Start: 2309
• Page End: 2316
• Publication Date: 2016-11-29
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000003375
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: To determine whether 18 F-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS). Methods: We evaluated the in vitro binding of 3 H-THK5351 in postmortem brain tissues from a patient with corticobasal degeneration (CBD). In clinical PET studies, 18 F-THK5351 retention in 5 patients with CBS was compared to that in 8 age-matched normal controls and 8 patients with Alzheimer disease (AD). Results: 3 H-THK5351 was able to bind to tau deposits in the postmortem brain with CBD. In clinical PET studies, the 5 patients with CBS showed significantly higher 18 F-THK5351 retention in the frontal, parietal, and globus pallidus than the 8 age-matched normal controls and patients with AD. Higher 18 F-THK5351 retention was observed contralaterally to the side associated with greater cortical dysfunction and parkinsonism. Conclusions: 18 F-THK5351 PET demonstrated high tracer signal in sites susceptible to tau deposition in patients with CBS. 18 F-THK5351 should be considered as a promising candidate radiotracer for the in vivo imaging of tau deposits in CBS.