Identification of emergent blaCMY-2-carrying Proteus mirabilis lineages by whole-genome sequencing. (January 2016)

• Record Type: Journal Article
• Authors: Mac Aogáin, M.; Rogers, T.R.; Crowley, B.
• Is Part Of: New microbes and new infections. Volume 9(2016)
• Page Start: 58
• Page End: 62
• Publication Date: 2016-01
• Subjects: blaCMY-2 -- genomics -- ICE -- PGI-1 -- Proteus mirabilis; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Communicable Diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1016/j.nmni.2015.11.012
• Languages: English
• ISSNs: 2052-2975

Abstract

Abstract: Whole-genome sequencing of 24 Proteus mirabilis isolates revealed the clonal expansion of two cefoxitin-resistant strains among patients with community-onset infection. These strains harboured bla CMY-2 within a chromosomally located integrative and conjugative element and exhibited multidrug resistance phenotypes. A predominant strain, identified in 18 patients, also harboured the PGI-1 genomic island and associated resistance genes, accounting for its broader antibiotic resistance profile. The identification of these novel multidrug-resistant strains among community-onset infections suggests that they are endemic to this region and represent emergent P. mirabilis lineages of clinical significance.