Eco-friendly synthesis of indo dyes mediated by a bacterial laccase. Issue 22 (1st September 2016)

• Record Type: Journal Article
• Authors: Sousa, Ana Catarina; Piedade, M. Fátima M. M.; Martins, Lígia O.; Robalo, M. Paula
• Is Part Of: Green chemistry. Volume 18:Issue 22(2016)
• Page Start: 6063
• Page End: 6070
• Publication Date: 2016-09-01
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c6gc02050j
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : An enzymatic route was identified for the production of indo dyes, through oxidative coupling mediated by the bacterial CotA-laccase. Abstract : Several aminoindamine and indoaniline dyes were obtained in good to excellent yields (64–98%) by oxidative cross-coupling between 1, 4-phenylenediamine (1 ), 4-aminophenol (2 ) or 2, 5-diaminotoluene (3 ) and several meta - and meta, para -substituted couplers (4a–j ) using a green biocatalyst, the bacterial enzyme CotA-laccase from Bacillus subtilis, in water and under mild conditions of pH and temperature. Our results show that the enzymatic route described represents an efficient and sustainable alternative to the chemical synthesis of indo dyes, with a potentially high impact in the cosmetic and hair dye industries.