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"On water" synthesis of N-unsubstituted pyrazoles: semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3, 5-disubstituted pyrazoles. Issue 2 (18th December 2014)
Record Type:
Journal Article
Title:
"On water" synthesis of N-unsubstituted pyrazoles: semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3, 5-disubstituted pyrazoles. Issue 2 (18th December 2014)
Main Title:
"On water" synthesis of N-unsubstituted pyrazoles: semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3, 5-disubstituted pyrazoles
Abstract : A method for the conversion of 4-substituted-2, 4-diketoester and 1-aryl-1, 3-diketones into pyrazole compounds under "on water" conditions has been developed. Abstract : A green, simple and highly efficient method for the synthesis of pyrazole-3-carboxylates and 3, 5-disubstituted pyrazoles by cyclization of 4-aryl(hetaryl, alkyl)-2, 4-diketoesters and 1, 3-diketones with semicarbazide hydrochloride under "on water" conditions has been developed. This method also does not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.