Antipsychotic drug exposure and risk of myocardial infarction. (22nd November 2016)

• Record Type: Journal Article
• Authors: Barbui, C.; Gastaldon, C.; Papola, D.; Ostuzzi, G.
• Is Part Of: Epidemiology and psychiatric sciences. Volume 26:Number 1(2017)
• Page Start: 18
• Page End: 21
• Publication Date: 2016-11-22
• Subjects: Antipsychotics, -- myocardial infarction, -- observational studies, -- psychosis, -- systematic reviews; Epidemiology -- Periodicals; Mental illness -- Periodicals; Community psychiatry -- Periodicals; 362.2
• DOI: 10.1017/S204579601600086X
• Languages: English
• ISSNs: 2045-7960

Abstract

Abstract : Patients experiencing psychoses and in need of antipsychotic agents may be exposed to a higher risk of myocardial infarction (MI) than the general population. As there have been no randomised studies investigating this association, a recent systematic review and meta-analysis included all observational studies that compared the incidence of MI among patients receiving antipsychotics v . no treatment. It found nine studies and calculated that the odds (risk) for developing MI were 1.88-fold higher in antipsychotic users compared with individuals who had not taken antipsychotic drugs. In this commentary, the results of this systematic review are discussed in view of their clinical implications for everyday clinical practice.