Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome. (5th March 2017)

• Record Type: Journal Article
• Authors: Carvalho, L.M.L.; Ferreira, C.N.; Sóter, M.O.; Sales, M.F.; Rodrigues, K.F.; Martins, S.R.; Candido, A.L.; Reis, F.M.; Silva, I.F.O.; Campos, F.M.F.; Gomes, K.B.
• Is Part Of: Molecular and cellular endocrinology. Volume 443(2017)
• Page Start: 155
• Page End: 162
• Publication Date: 2017-03-05
• Subjects: Polycystic Ovary Syndrome -- Microparticles -- Platelets -- Leukocytes -- Endothelial cells -- Tissue factor; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2017.01.017
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women. Highlights: PCOS women present increased total microparticles (MPs). MPs derived from platelets and leuckocytes are increased in PCOS group. PCOS women present higher MPs derived from endothelial cells.