Antibiotic prophylaxis for premature rupture of membranes and perinatal outcome. (4th March 2017)

• Record Type: Journal Article
• Authors: Barišić, Tatjana; Mandić, Vjekoslav; Tomić, Vajdana; Zovko, Ana; Novaković, Gorjana
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 30:Number 5(2017)
• Page Start: 580
• Page End: 584
• Publication Date: 2017-03-04
• Subjects: Antibiotic prophylaxis -- perinatal outcomes -- premature rupture of membranes; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1178228
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Aim : To evaluate the perinatal outcomes of newborns after premature rupture of membranes (PROM) at the term according to the timing of initial antibiotic administration. Material and methods : This is a retrospective, cohort study investigating perinatal outcomes of newborns in pregnant women with PROM at the term who were treated with ampicillin within or after 6 h from the PROM. Statistical analysis was performed using Student's t -test for continuous variables test and chi-square or for categorical data. Results : The study involved 144 pregnant women with PROM and their newborns, a lower number received antibiotics after birth were in the group who received antibiotics within 6 h of PROM (26.4% versus 73.6%), the mediane values of C-reactive protein were lower (3.0 ± 2.9 mg/l versus 6.1 ± 7.3 mg/l; p < 0.001), their newborns remained shorter in hospital after birth (4.13 versus 4.94; p =0.023) and time between PROM and delivery was shorter ( p < 0.001). In group who received prophylactic antibiotics after 6 h of the PROM had significantly higher frequency of infection in newborns (45.3% versus 15.4%), and higher number of chorioamnionitis (9.72% versus 3, 47%) compared to group who received antibiotics within 6h. Conclusion : Timely usage of antibiotic prophylaxis and shorter time between PROM and delivery improve perinatal outcomes.