Clot Burden Score on Baseline Computerized Tomographic Angiography and Intra-Arterial Treatment Effect in Acute Ischemic Stroke. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Treurniet, Kilian M.; Yoo, Albert J.; Berkhemer, Olvert A.; Lingsma, Hester F.; Boers, Anna M.M.; Fransen, Puck S.S.; Beumer, Debbie; van den Berg, Lucie A.; Sprengers, Marieke E.S.; Jenniskens, Sjoerd F.M.; Lycklama À Nijeholt, Geert J.; van Walderveen, Marianne A.A.; Bot, Joseph C.J.; Beenen, Ludo F.M.; van den Berg, René; van Zwam, Wim H.; van der Lugt, Aad; van Oostenbrugge, Robert J.; Dippel, Diederik W.J.; Roos, Yvo B.W.E.M.; Marquering, Henk A.; Majoie, Charles B.L.M.; Schonewille, Wouter J.; Albert Vos, Jan; Nederkoorn, Paul J.; Wermer, Marieke J.H.; Staals, Julie; Hofmeijer, Jeannette; van Oostayen, Jacques A.; Boiten, Jelis; Brouwer, Patrick A.; Emmer, Bart J.; de Bruijn, Sebastiaan F.; van Dijk, Lukas C.; Kappelle, L. Jaap; Lo, Rob H.; van Dijk, Ewoud J.; de Vries, Joost; de Kort, Paul L.M.; van den Berg, Jan S.P.; van Rooij, Willem Jan J.; van Hasselt, Boudewijn A.A.M.; Aerden, Leo A.M.; Dallinga, René J.; Visser, Marieke C.; Vroomen, Patrick C.; Eshghi, Omid; Schreuder, Tobien H.C.M.L.; Heijboer, Roel J.J.; Keizer, Koos; Tielbeek, Alexander V.; den Hertog, Heleen M.; Gerrits, Dick G.; van den Berg-Vos, Renske M.; Karas, Giorgos B.; Koudstaal, Peter J.; Boiten, Jelis; van Dijk, Ewoud J.; Wermer, Marieke J.H.; Flach, H. Zwenneke; Steyerberg, Ewout W;
• Is Part Of: Stroke. Volume 47:Issue 12(2016)
• Publication Date: 2016-12
• Subjects: intracranial embolism -- neuroimaging -- stroke -- thrombectomy -- thrombolytic therapy; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.116.014565
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Background and Purpose—: A high clot burden score (CBS) is associated with favorable outcome after intravenous treatment for acute ischemic stroke. The added benefit of intra-arterial treatment might be less in these patients. The aim of this exploratory post hoc analysis was to assess the relation of CBS with neurological improvement and endovascular treatment effect. Methods—: For 499 of 500 patients in the MR CLEAN study (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), the CBS was determined. Ordinal logistic regression models with and without main baseline prognostic variables were used to assess the association between CBS (continuous or dichotomized at CBS of 6) and a shift toward better outcome on the modified Rankin Scale. The model without main baseline prognostic variables only included treatment allocation and CBS. Models with and without a multiplicative interaction term of CBS and treatment were compared using the χ 2 test to assess treatment effect modification by CBS. Results—: Higher CBS was associated with a shift toward better outcome on the modified Rankin Scale; adjusted common odds ratio per point CBS was 1.12 (95% confidence interval, 1.04–1.20]. Dichotomized CBS had an adjusted common odds ratio of 1.67 (95% confidence interval, 1.12–2.51). Both effect estimates were slightly attenuated by adding baseline prognostic variables. The addition of the interaction terms did not significantly improve the fit of the models. There was a small and insignificant increase of intra-arterial treatment efficacy in the high CBS group. Conclusions—: A higher CBS is associated with improved outcome and may be used as a prognostic marker. We found no evidence that CBS modifies the effect of intra-arterial treatment. Clinical Trial Registration—: URL:http://www.trialregister.nl . Unique identifier: NTR1804. URL:http://www.controlled-trials.com . Unique identifier: ISRCTN10888758. Abstract : Supplemental Digital Content is available in the text.