Bacillus cereus bacteraemia: comparison between haematologic and nonhaematologic patients. (January 2017)

• Record Type: Journal Article
• Authors: Tusgul, S.; Prod'hom, G.; Senn, L.; Meuli, R.; Bochud, P.-Y.; Giulieri, S.G.
• Is Part Of: New microbes and new infections. Volume 15(2017)
• Page Start: 65
• Page End: 71
• Publication Date: 2017-01
• Subjects: Bacillus cereus -- bacteraemia -- central nervous system -- intravascular catheter -- neutropenia; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Communicable Diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1016/j.nmni.2016.11.011
• Languages: English
• ISSNs: 2052-2975

Abstract

Abstract: Bacillus cereus bacteraemia can be severe, especially among patients with haematologic malignancy. We retrospectively reviewed first episodes of true B. cereus bacteraemia (more than one positive bottle plus signs of infection) at our institution between 1997 and 2013 with the aim to compare haematologic versus nonhaematologic patients and analyse episodes with complicated outcome. Among 56 episodes of positive-blood cultures for B. cereus, 21 were considered significant. Median age was 54 years (range 23–82 years). Ten patients (48%) had a haematologic malignancy; all were neutropenic at the time of B. cereus bacteraemia. Nonhaematologic patients were either intravenous drug users ( n = 3, 14%), polytraumatized ( n = 3, 14%) or had multiple chronic comorbidities ( n = 5, 24%). Most episodes were hospital acquired (15, 71%). Sources of bacteraemia were intravascular catheter ( n = 11, 52%), digestive tract ( n = 6, 29%), drug injection ( n = 3, 14%) and wound ( n = 1, 5%). Adequate antibiotic therapy was provided to 18 patients (86%) during a median of 17 days (range 2–253 days). The intravascular catheter was removed in eight cases (42%). Three haematologic patients had a complicated course with neurologic complications (meningoencephalitis and cerebral abscesses). Complications appeared to be associated with catheter infection (100% of complicated cases vs. 29% of noncomplicated cases). In conclusion, B. cereus bacteraemia can have a complicated course in a subset of patients, mainly those with haematologic malignancy. Catheter infection may be associated with a worse outcome with frequent neurologic complications.