The clinical significance of apoptosis and M30 expression in colonic cancer progression. (14th June 2013)

• Record Type: Journal Article
• Authors: Kykalos, Stylianos; Dimitroulis, Dimitrios; Ntikoudi, Evangelia; Karayiannakis, Anastasios
• Is Part Of: Journal of receptor and signal transduction research. Volume 33:Number 4(2013)
• Page Start: 255
• Page End: 259
• Publication Date: 2013-06-14
• Subjects: Cleaved CK18 -- colon cancer -- liver metastasis; Cell receptors -- Periodicals; Cellular signal transduction -- Periodicals; 571.6
• DOI: 10.3109/10799893.2013.802804
• Languages: English
• ISSNs: 1079-9893

Abstract

Abstract: Background/aim : The aim of this study is to identify the significance of M30, an early apoptosis indicator, in colorectal cancer and its liver metastasis. Patients and methods : The expression of M30 was immunohistochemically estimated at colonic and liver metastatic tissues of 66 patients. The results were correlated to clinical and pathological features of the tumors. Results : High expression of M30 was observed in 15.5% of cases. No metastatic tissue showed expression of M30, while stage D tumors (metastasis included) showed a statistic significant lower expression of M30, when compared to earlier tumor stages. Conclusion : Low expression of M30 implies the development of resistance mechanisms against apoptosis, facilitating the progression of colon cancer.