Quaternary Ammonium Salt‐Promoted Multi‐Component Reaction in Water: Access to 3‐Alkyl‐2, 3‐Dihydro‐1H‐Isoindolin‐1‐One Derivatives. Issue 1 (9th December 2016)

• Record Type: Journal Article
• Authors: Han, Fu‐Zhong; Su, Bo‐Bo; Jia, Li‐Na; Wang, Peng‐Wei; Hu, Xiang‐Ping
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 1(2017)
• Page Start: 146
• Page End: 152
• Publication Date: 2016-12-09
• Subjects: quaternary ammonium salt -- multi-component reaction -- β-keto acid -- isoindolinone -- decarboxylation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600944
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A concise synthesis of alkyl‐2, 3‐dihydro‐1H‐isoindolin‐1‐one derivatives from 2‐formyl benzoic acid, β‐keto acid, and ammonia or primary amine was developed via a quaternary ammonium salt‐promoted multi‐component sequence of decarboxylative alkylation/lactamization reaction in water, in which the target products were obtained in good to excellent yields. Abstract :