Drug Delivery: Zero‐Order Antibiotic Release from Multilayer Contact Lenses: Nonuniform Drug and Diffusivity Distributions Produce Constant‐Rate Drug Delivery (Adv. Healthcare Mater. 3/2017). Issue 3 (February 2017)

• Record Type: Journal Article
• Authors: Guzman, Gustavo; Es‐haghi, Siamak Shams; Nugay, Turgut; Cakmak, Mukerrem
• Is Part Of: Advanced healthcare materials. Volume 6:Issue 3(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02
• Subjects: amphiphilic conetworks -- contact lenses -- drug release -- zero‐order; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201770016
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article 1600775, Mukerrem Cakmak and co‐workers present a novel approach to zero‐order constant‐rate drug delivery from three‐layer bimodal amphiphilic conetwork contact lenses. Combined effects of nonuniform distribution of drug loading and diffusion constants maintains low local drug concentration at the lens–fluid interface and yields zero‐order drug delivery. The release rates of topical antibiotics provide constant‐rate therapeutic‐level delivery with appropriate oxygen permeability for at least 30 h.