Disease-related and drug-induced skin manifestations in inflammatory bowel disease. (4th March 2017)

• Record Type: Journal Article
• Authors: Hindryckx, Pieter; Novak, Gregor; Costanzo, Antonio; Danese, Silvio
• Is Part Of: Expert review of gastroenterology & hepatology. Volume 11:Number 3(2017)
• Page Start: 203
• Page End: 214
• Publication Date: 2017-03-04
• Subjects: Skin lesions -- inflammatory bowel disease -- extra-intestinal -- drug-induced -- cutaneous; Gastroenterology -- Periodicals; Liver -- Diseases -- Periodicals; 616.3
• DOI: 10.1080/17474124.2017.1283985
• Languages: English
• ISSNs: 1747-4124

Abstract

ABSTRACT: Introduction : Skin manifestations are common in patients with inflammatory bowel diseases (IBD) and can be part of a concomitant illness with a shared genetic background, an extra-intestinal manifestation of the disease, or a drug side-effect. Areas covered : We provide a practical overview of the epidemiology, pathogenesis, diagnosis, therapeutic approach and prognosis of the most frequent disease-related and drug-induced cutaneous manifestations in IBD, illustrated by cases encountered in our clinical practice. Among the most frequently encountered IBD-related lesions are erythema nodosum, pyoderma gangrenosum and Sweet's syndrome. Common skin manifestations with a strong association to TNF antagonists are local injection site reactions, psoriasiform lesions, cutaneous infections, vasculitides and lupus-like syndromes. In addition, we discuss the relation of thiopurines and TNF antagonists with the risk of skin cancer. Expert commentary : We hope this review will help caretakers involved in the management of IBD patients to recognize the lesions and to manage them in close collaboration with a dedicated dermatologist.