Three new phenylpropanoids from Lavandula angustifolia and their bioactivities. Issue 12 (18th June 2017)

• Record Type: Journal Article
• Authors: Tang, Shiyun; Shi, Jianlian; Liu, Chunbo; Jiang, Rui; Zhao, Wei; Liu, Xin; Xiang, Nengjun; Chen, Yongkuan; Shen, Qinpeng; Miao, Mingming; Liu, Zhihua; Yang, Guangyu
• Is Part Of: Natural product research. Volume 31:Issue 12(2017)
• Page Start: 1351
• Page End: 1357
• Publication Date: 2017-06-18
• Subjects: Lavandula angustifolia -- phenylpropanoids -- anti-tobacoo mosaic virus activities -- cytotoxicity activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1247081
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new phenylpropanoids, 3-(3, 4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate (1 ), 3-hydroxy-1-(3, 4-dimethoxy-5-methylphenyl)propan-1-one (2 ), and 3-hydroxy-1-(4-methylbenzo[ d ][1, 3]dioxol-6-yl) propan-1-one (3 ), together with three known phenylpropanoids (4 –6 ) were isolated from the whole plant of Lavandula angustifolia . Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds1 –6 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds1 –3 showed high anti-TMV activity with inhibition rate of 35.2, 38.4 and 33.9%. These rates are higher than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 26.8–28.9%, respectively. Compounds1 –6 also showed weak inhibitory activities against some tested human tumour cell lines with IC50 values in the range of 3.8–8.8 μM. Abstract :