Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil. Issue 12 (18th June 2017)

• Record Type: Journal Article
• Authors: Zachow, Lucimara L.; Ávila, Janaína M.; Saldanha, Geovane A.; Mostardeiro, Marco A.; da Silva, Ubiratan F.; Morel, Ademir F.; Dalcol, Ionara I.
• Is Part Of: Natural product research. Volume 31:Issue 12(2017)
• Page Start: 1459
• Page End: 1463
• Publication Date: 2017-06-18
• Subjects: Lamiaceae -- Leonurus sibiricus -- prolyl oligopeptidase -- acetylcholinesterase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1255890
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors. Extracts obtained by maceration were active against POP (53–58%), but showed weak activity against AChE. The isolated leojaponin and leonurine were evaluated as POP inhibitors. Abstract :