Separation of antioxidant and α-glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus. Issue 12 (18th June 2017)

• Record Type: Journal Article
• Authors: Wang, Yan-Ming; Zhao, Jian-Qiang; Yang, Jun-Li; Tao, Yan-Duo; Mei, Li-Juan; Shi, Yan-Ping
• Is Part Of: Natural product research. Volume 31:Issue 12(2017)
• Page Start: 1365
• Page End: 1369
• Publication Date: 2017-06-18
• Subjects: Asterothamnus centrali-asiaticus -- flavonoids -- antioxidants -- α-glucosidase inhibitors; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1247083
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new flavonoid, along with 16 known ones, was separated from the aerial parts of Asterothamnus centrali - asiaticus . Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR techniques and HRESIMS. To confirm the structure of the new compound, computational prediction of its 13 C chemical shifts was performed. All of the 17 flavonoids were reported from A. centrali - asiaticus for the first time. In addition, all flavonoids were evaluated for their antioxidant and α -glucosidase inhibitory activities. The results showed that 10 of them exhibited antioxidant activity. Meanwhile, four flavonoids displayed α -glucosidase inhibitory effect with IC50 values ranging from 38.9 to 299.7 μM. Abstract :