New mono-ether of glycerol and triterpenes with DPPH radical scavenging activity from Cameroonian propolis. Issue 12 (18th June 2017)

• Record Type: Journal Article
• Authors: Talla, Emmanuel; Tamfu, Alfred Ngenge; Gade, Isaac Sylvère; Yanda, Lambert; Mbafor, Joseph Tanyi; Laurent, Sophie; Elst, Luce Vander; Popova, Milena; Bankova, Vassya
• Is Part Of: Natural product research. Volume 31:Issue 12(2017)
• Page Start: 1379
• Page End: 1389
• Publication Date: 2017-06-18
• Subjects: Propolis -- GC-MS profiles -- NMR analysis -- triterpenes -- 1′-O-eicosanyl glycerol -- DPPH· radical scavenging activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1253077
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The extracts of some propolis samples were analysed by GC-MS and then purified by column chromatography. The latter led to the isolation of a new mono-ether of glycerol, 1′-O-eicosanyl glycerol and a new triterpene, methyl-3β, 27-dihydroxycycloart-24-en-26-oate together with known triterpenoids namely betulin, 3β-hydroxylanostan-9, 24-dien-21-oic acid, mangiferonic acid, a mixture of ambolic acid and β-sitosterol, 3β-hydroxycycloartan-12, 24(25)-diene and 27-hydroxymangiferonic acid. The DPPH radical scavenging potential of some extracts and compounds were measured. The radical scavenging activity varied from Hexane extract of Foumban propolis (IC50 = 5.6 mg/mL) to Methanol extract of Foumban propolis (IC50 = 1.07 mg/mL) for the extracts and from 3β-hydroxylanostan-9, 24-dien-21-oic acid (IC50 = 1.22 mg/mL) to 1′-O-eicosanyl glycerol (IC50 = 0.93 mg/mL) for the compounds. Activities of samples were moderate as they remained closer to those of the standard antioxidants Gallic acid (IC50 = 0.30 mg/mL) and vitamin C (IC50 = 0.80 mg/mL), especially 1′-O-eicosanyl glycerol, the most active compound. Abstract :