Biological activities of triterpenoids from Poraqueiba sericea stems. Issue 11 (3rd June 2017)

• Record Type: Journal Article
• Authors: Zebiri, Ilhem; Haddad, Mohamed; Duca, Laurent; Sauvain, Michel; Paloque, Lucie; Cabanillas, Billy; Rengifo, Elsa; Behr, Jean-Bernard; Voutquenne-Nazabadioko, Laurence
• Is Part Of: Natural product research. Volume 31:Issue 11(2017)
• Page Start: 1333
• Page End: 1338
• Publication Date: 2017-06-03
• Subjects: Poraqueiba sericea -- Icacinaceae -- triterpenes -- secoiridoids; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1241998
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Eleven compounds were isolated from Poraqueiba sericea stems and identified as niga-ichigoside-F1 (1 ), trachelosperoside B1 (2 ), 4-epi-niga-ichigoside (7 ), 19α-hydroxyasiatic acid (3 ), myrianthic acid (4 ), hyptatic acid (5 ), trachelosperogenin B (6 ), arjunolic acid (8 ), and trachelosperogenin E (9 ), secologanoside (10 ) and secoxyloganin (11 ). Compounds1 –11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1 –6 and8 –11 were tested for their cytotoxic activities on fibroblasts, 1 –3, 5 –6, 8 –11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and1 –2, 5 and7 –10 were tested using bioautography for their β-glucosidase. No antileishmanial activity was detected; compounds1, 2 and11 showed a moderate cytotoxic activity with IC50 17.7, 20.5 and 10.9 μg/mL, respectively; compounds2, 8, 9 and10 gave a percentage of inhibition ranging from 13 to 16% (at 50 μg/mL) and compounds1 and2 showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays. Abstract :