Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells. Issue 11 (3rd June 2017)

• Record Type: Journal Article
• Authors: Han, Qinghe; Wang, Haiyu; Xiao, Chong; Fu, Ben-Dong; Du, Chong-Tao
• Is Part Of: Natural product research. Volume 31:Issue 11(2017)
• Page Start: 1339
• Page End: 1342
• Publication Date: 2017-06-03
• Subjects: Oroxylin A -- PC12 cells -- ROS; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1244193
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12 cells were exposed to oroxylin A and hydrogen peroxide solutions and measured. Oroxylin A significantly reduced the levels of intracellular calcium and reactive oxygen species and increased the levels of CAT and Mn/SOD. Oroxylin A also inhibited the activation of caspase-3. These results suggest that treatment of PC12 cells with oroxylin A inhibits H2 O2 -induced oxidative stress. Abstract :