More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?. Issue 1 (1st January 2017)

• Record Type: Journal Article
• Authors: Presman, Diego M.; Hager, Gordon L.
• Is Part Of: Transcription. Volume 8:Issue 1(2017)
• Page Start: 32
• Page End: 39
• Publication Date: 2017-01-01
• Subjects: DNA binding -- dimer -- glucocorticoid receptor -- monomer -- steroid receptors -- tetramer; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2016.1249045
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer.