Transcriptional control by G-quadruplexes: In vivo roles and perspectives for specific intervention. Issue 1 (1st January 2017)

• Record Type: Journal Article
• Authors: Armas, Pablo; David, Aldana; Calcaterra, Nora B.
• Is Part Of: Transcription. Volume 8:Issue 1(2017)
• Page Start: 21
• Page End: 25
• Publication Date: 2017-01-01
• Subjects: antisense -- embryonic development -- noggin3 -- oligonucleotide -- zebrafish; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2016.1243505
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: G-quadruplexes are non-canonical DNA secondary structures involved in several genomic and molecular processes. Here, we summarize the main G-quadruplex features and evidences proving the in vivo role on the transcriptional regulation of genes required for zebrafish embryonic development. We also discuss alternative strategies for specifically interfering G-quadruplex in vivo .