An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. Issue 10 (19th May 2017)

• Record Type: Journal Article
• Authors: Pejin, Boris; Ciric, Ana; Dimitric Markovic, Jasmina; Glamoclija, Jasmina; Nikolic, Milos; Sokovic, Marina
• Is Part Of: Natural product research. Volume 31:Issue 10(2017)
• Page Start: 1177
• Page End: 1180
• Publication Date: 2017-05-19
• Subjects: Flavanone-7-O-glucoside -- delphinidin -- infectious diseases -- bacterial resistance -- anti-biofilm activity -- low sub-MIC; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1222386
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins. Abstract :