Prognostic values of VEGF and IL-8 in malignant pleural effusion in patients with lung cancer. (20th May 2013)

• Record Type: Journal Article
• Authors: Cheng, Daye; Kong, Hong; Li, Yunhui
• Is Part Of: Biomarkers. Volume 18:Number 5(2013)
• Page Start: 386
• Page End: 390
• Publication Date: 2013-05-20
• Subjects: Cytokine -- pleural effusion -- prognosis -- tumor; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.797499
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Objective : The aim of this study was to evaluate the prognostic value of VEGF and IL-8 in pleural effusion in patients with lung cancer. Materials and method : Commercially available ELISA was used to determine VEGF and IL-8 levels. Results : The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis. But, IL-8 was only correlated with lymph node metastasis. Univariate and multivariate analysis revealed elevated VEGF level was an independent predictor of shorter OS and DFS. Conclusion : VEGF could be an important component that contributes to pleural effusion formation, and an important prognostic factor for lung cancer.