Atomic force microscopy combined with optical microscopy for cells investigation. Issue 1 (21st June 2016)

• Record Type: Journal Article
• Authors: Cascione, Mariafrancesca; de Matteis, Valeria; Rinaldi, Rosaria; Leporatti, Stefano
• Other Names: Toca‐Herrera José L. guestEditor.
• Is Part Of: Microscopy research and technique. Volume 80:Issue 1(2017)
• Page Start: 109
• Page End: 123
• Publication Date: 2016-06-21
• Subjects: atomic force microscopy -- cells -- fluorescence microscopy -- confocal laser scanning microscopy -- total internal reflection fluorescence microscopy; Electron microscopy -- Technique -- Periodicals; Microscopy -- Periodicals; Microscopy -- Technique -- Periodicals; 502.825
• DOI: 10.1002/jemt.22696
• Languages: English
• ISSNs: 1059-910X

Abstract

ABSTRACT: This review reports on the combined use of the atomic force microscopy (AFM) and several type of optical/fluorescence/laser scanning microscopy for investigating cells. It is shown that the hybrid systems of AFM with optical‐derived microscopies enable to study in detail cell surface properties (such as topography), their mechanical properties (e.g., Young's modulus) mechanotransduction phenomena and allow to gain insight into biological‐related pathways and mechanisms in the complex nanoworld of cells. Microsc. Res. Tech. 80:109–123, 2017 . © 2016 Wiley Periodicals, Inc.