Predictive factors and treatment outcome of laryngeal carcinoma recurrence. Issue 3 (30th November 2016)

• Record Type: Journal Article
• Authors: Haapaniemi, Aaro; Väisänen, Janne; Atula, Timo; Alho, Olli‐Pekka; Mäkitie, Antti; Koivunen, Petri
• Is Part Of: Head & neck. Volume 39:Issue 3(2017)
• Page Start: 555
• Page End: 563
• Publication Date: 2016-11-30
• Subjects: laryngeal cancer -- prognosis -- surgery -- radiotherapy -- recurrence; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24642
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence. Methods: A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy ( n = 316) was analyzed. Results: Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment. The World Health Organization (WHO) performance status >0, neck metastasis at presentation, and nonsurgical treatment were independent prognostic factors for recurrence. Patients with local recurrence had a 5‐year overall survival (OS) of 53% compared with 5% in patients with regional/distant recurrences. OS for glottic and nonglottic laryngeal SCC recurrence was 45% and 0%, respectively. Conclusion: The type of treatment affected the risk of recurrence in this retrospective series. Local recurrences carried a chance for successful salvage treatment. Routine follow‐up beyond 36 months remains controversial. © 2016 Wiley Periodicals, Inc. Head Neck 39: 555–563, 2017