Ultra‐thin layer chromatography with integrated silver colloid‐based SERS detection. Issue 2 (7th September 2016)

• Record Type: Journal Article
• Authors: Wallace, Ryan A.; Lavrik, Nickolay V.; Sepaniak, Michael J.
• Other Names: Foret Frantisek guestEditor.; Kutter Jrög P. guestEditor.
• Is Part Of: Electrophoresis. Volume 38:Issue 2(2017)
• Page Start: 361
• Page End: 367
• Publication Date: 2016-09-07
• Subjects: Photolithography -- SERS -- Ultra‐thin layer chromatograpy; Electrophoresis -- Periodicals; Electrophoresis -- Periodicals; 541.372
• DOI: 10.1002/elps.201600319
• Languages: English
• ISSNs: 0173-0835

Abstract

Abstract : Simplified lab‐on‐a‐chip techniques are desirable for quick and efficient detection of analytes of interest in the field. The following work involves the use of deterministic pillar arrays on the micro‐scale as a platform to separate compounds, and the use of Ag colloid within the arrays as a source of increased signal via surface enhanced Raman spectroscopy (SERS). One problem traditionally seen with SERS surfaces containing Ag colloid is oxidation; however, our platforms are superhydrophobic, reducing the amount of oxidation taking place on the surface of the Ag colloid. This work includes the successful separation and SERS detection of a fluorescent dye compounds (resorufin and sulforhodamine 640), fluorescent anti‐tumor drugs (Adriamycin and Daunomycin), and purine and pyrimidine bases (adenine, cytosine, guanine, hypoxanthine, and thymine).