Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells. Issue 2 (1st February 2017)

• Record Type: Journal Article
• Authors: Bae, Joon Young; Lee, Jin Woo; Jin, Qinghao; Jang, Hari; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Lee, Moon Soon; Hwang, Bang Yeon
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 2(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-01
• Subjects: Bletilla striata -- Orchidaceae -- Flavan‐3‐ol -- Nitric oxide production -- Bletillanol A -- Bletillanol B; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201600243
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : Bioassay‐guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C‐methylated flavan‐3‐ols, bletillanols A (1 ) and B (2 ), along with ten known compounds (3 – 12 ). Their structures were determined by using extensive spectroscopic analysis including 1D‐, 2D‐NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS‐stimulated RAW 264.7 cells. Abstract :