Cytotoxic and Anti‐inflammatory Sesquiterpenes from Ainsliaea henryi. Issue 2 (10th January 2017)

• Record Type: Journal Article
• Authors: Zeng, Ren‐Tao; Dong, Xue‐Yun; Fang, Xing; Yang, Niao; Shi, Zhi‐Ran; Zhuo, Zhi‐Guo; Shen, Yun‐Heng; Zhang, Wei‐Dong
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 2(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-10
• Subjects: Ainsliaea species -- Ainsliaea henryi -- Sesquiterpenoids -- NO production -- Cytotoxic activities; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201600210
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : Three new sesquiterpenoids, 4 α ‐hydroxyeudesm‐11(13)‐en‐12‐yl 3‐methylbutanoate (1 ), diaspanolide E (2 ), and (13 α )‐germacra‐1(10), 4‐dien‐12, 8 α ‐olid‐15‐oic acid (3 ), along with eight known sesquiterpenoids (4 –11 ), were isolated from the aerial parts of Ainsliaea henryi . The chemical structures of compounds1 –3 were elucidated by spectroscopic analysis (1D‐, 2D‐NMR, MS and HR/MS). All isolates were evaluated for their inhibitory activities against nitric oxide (NO) production in lipopolysaccharide‐induced RAW264.7 macrophage cells. Compound10 exhibited significantly inhibition against NO release with an IC 50 value of 6.54 ± 0.16 μm . Also, all isolated compounds were tested for cytotoxicity against three human tumor cell lines A549, MGC803, and HCT116, among which compound5 significantly inhibited the proliferation of MGC803 cell lines with an IC 50 value of 2.2 ± 0.2 μm . Abstract :