Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report. (27th June 2013)

• Record Type: Journal Article
• Authors: Eleuteri, Ermanno; Mezzani, Alessandro; Di Stefano, Antonino; Vallese, Davide; Gnemmi, Isabella; Delle Donne, Lorena; Taddeo, Adriano; Della Bella, Silvia; Giannuzzi, Pantaleo
• Is Part Of: Biomarkers. Volume 18:Number 5(2013)
• Page Start: 418
• Page End: 424
• Publication Date: 2013-06-27
• Subjects: Cardiovascular disease -- growth factors/cytokines/inflammatory mediators -- sports science/exercise; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.805342
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.