Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies. (2nd January 2017)

• Record Type: Journal Article
• Authors: Maymon, Ron; Trahtenherts, Alla; Svirsky, Ran; Melcer, Yaakov; Madar-Shapiro, Liora; Klog, Esther; Meiri, Hamutal; Cuckle, Howard
• Is Part Of: Hypertension in pregnancy. Volume 36:Number 1(2017)
• Page Start: 108
• Page End: 115
• Publication Date: 2017-01-02
• Subjects: PP13 -- PlGF -- PAPP-A -- Doppler UTPI -- MAP; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2016.1242605
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objectives : Construct a new preeclampsia predicting algorithm in twins. Methods : Twins sampled at 10–13 and 16–20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk factors. Results : The cohort included 9 PE (18 samples) and 96 unaffected cases (175 samples) twin pregnant women. The algorithm constructed of PlGF, PAPP-A, PP13, Doppler UTPI, and MAP with prior risk factors generated an area under the curve of 0.918, 75% detection rate for 10% false-positive rate. Conclusions : The algorithm effectively forecasted twin risk to develop PE.