Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. (7th February 2017)

• Record Type: Journal Article
• Authors: Vishwakarma, Supriya; Agarwal, Rahul; Goel, Sudhir K.; Panday, Rajendra K.; Singh, Renu; Sukumaran, Ravi; Khare, Sarita; Kumar, Ashok
• Is Part Of: Cancer investigation. Volume 35:Number 2(2017)
• Page Start: 139
• Page End: 141
• Publication Date: 2017-02-07
• Subjects: Head and neck cancer -- sphingosine-1-phosphate -- sphingosine kinase 2 -- lipid phosphate phosphatase -- miR-95-3p; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2016.1272695
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes ( SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C ) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of SphK1 and SGPP1 genes was up-regulated significantly in 70% and 75% OSCC tumors respectively. Importantly, expression of SphK2 and PPAP2B was down-regulated in the tumor tissues of 70% OSCC patients. Expression of SphK2 and PPAP2B negatively correlated with tumor-node-metastasis (TNM) staging and tumor volume respectively. Furthermore, LPP1 is an independent predictor of TNM staging and lymph node ratio.