MicroRNA-196a as a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma. (7th February 2017)

• Record Type: Journal Article
• Authors: Fendereski, Mona; Zia, Mohammad Farid; Shafiee, Mohammad; Safari, Forousan; Saneie, Mohammad Hosien; Tavassoli, Manoochehr
• Is Part Of: Cancer investigation. Volume 35:Number 2(2017)
• Page Start: 78
• Page End: 84
• Publication Date: 2017-02-07
• Subjects: ESCC -- miR-196a -- biomarker -- saliva; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2016.1254228
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue ( p = .002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC. In addition, molecular pathway enrichment analysis of microRNA (miR)-196a determined focal adhesion, spliceosome and p53 signaling pathways as the most relevant pathways with miR-196a targetome.