Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice. (7th February 2017)

• Record Type: Journal Article
• Authors: Oishi, Katsutaka; Ohkura, Naoki; Yasumoto, Yuki; Yamamoto, Saori
• Is Part Of: Chronobiology international. Volume 34:Number 2(2017)
• Page Start: 254
• Page End: 259
• Publication Date: 2017-02-07
• Subjects: Circadian clocks -- circadian rhythm -- feeding behavior -- fibrinolysis -- mouse -- plasminogen activator inhibitor-1; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.1080/07420528.2016.1256299
• Languages: English
• ISSNs: 0742-0528

Abstract

ABSTRACT: To evaluate the involvement of the day-night feeding cycle in the circadian regulation of circulating plasminogen activator inhibitor-1 (PAI-1) concentrations, mice were fed with a diet for eight hours during either daytime (DF) or nighttime (NF) for one week. The reversed feeding cycle did not affect the circadian phases of plasma PAI-1 levels as well as the nocturnal wheel-running activity, although the phase of Pai-1 mRNA expression was significantly advanced for 8.6 hours in the livers of DF, compared with NF mice. The day-night feeding cycle is not a critical Zeitgeber for circadian rhythm of circulating PAI-1.