An in-Depth Analysis of the Swelling, Mechanical, Electrical, and Drug Release Properties of Agar–Gelatin Co-Hydrogels. Issue 6 (13th April 2017)

• Record Type: Journal Article
• Authors: Pandey, Preeti Madhuri; Nayak, Suraj K.; Shaw, Gauri Shankar; Uvanesh, K.; Banerjee, I.; Al-Zahrani, S. M.; Anis, Arfat; Pal, Kunal
• Is Part Of: Polymer-plastics technology and engineering. Volume 56:Issue 6(2017)
• Page Start: 667
• Page End: 677
• Publication Date: 2017-04-13
• Subjects: Agar -- co-hydrogels -- drug release -- gelatin -- impedance spectroscopy -- viscoelasticity; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Periodicals; Engineering -- Periodicals; Plastics -- Periodicals; 668.9
• DOI: 10.1080/03602559.2016.1211694
• Languages: English
• ISSNs: 0360-2559

Abstract

ABSTRACT: Agar–gelatin-based co-hydrogels were prepared with different compositions of the agar and the gelatin fractions. The intermolecular hydrogen bonding was higher in the co-hydrogels as compared to the gelatin hydrogel. Swelling studies indicated diffusion-mediated swelling. The electrical stability of the co-hydrogels was higher as compared to the gelatin hydrogel. Though the firmness of the co-hydrogels was higher, Weichert model of viscoelasticity indicated that the inherent mechanical stability of the gelatin hydrogel was superior. The release of ciprofloxacin hydrochloride was predominately Fickian diffusion-mediated. In gist, the co-hydrogels can be tried as polymeric constructs for controlled drug delivery applications. GRAPHICAL ABSTRACT: