Cognitive impairments in patients with first episode psychosis: The relationship between neurophysiological and neuropsychological assessments. (February 2017)

• Record Type: Journal Article
• Authors: Morales-Muñoz, Isabel; Jurado-Barba, Rosa; Fernández-Guinea, Sara; Álvarez-Alonso, María José; Rodríguez-Jiménez, Roberto; Jiménez-Arriero, Miguel Angel; Rubio, Gabriel
• Is Part Of: Journal of clinical neuroscience. Volume 36(2017:Feb.)
• Page Start: 80
• Page End: 87
• Publication Date: 2017-02
• Subjects: First episode psychosis -- Event-related potentials -- MCCB -- Cognition; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2016.10.023
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: We examine a sample of patients with first episode psychosis of schizophrenia. We study the association between neuropsychological and neurophysiological deficits. Early ERP components are still preserved in early stages of schizophrenia. MCCB is a valid battery for studying cognition in early stages of schizophrenia. We show converging measures for attentional deficits in schizophrenia. Abstract: Cognitive deficits in schizophrenia have been widely reported. Neurophysiological and neuropsychological assessments have been conducted to study these impairments. Event-related potentials (ERPs) are relevant markers of cognitive deficits in schizophrenia, and reductions in specific ERP components have been found. The MATRICS Consensus Cognitive Battery (MCCB) was developed to obtain a consensus battery for the assessment of cognitive deficits in schizophrenia. Here, we aimed to study modulations of several ERP components in first episode psychosis (FEP). We also examined neuropsychological deficits using the MCCB, and correlations between ERP and MCCB impairments. Thirty-eight FEP patients were compared to thirty-eight healthy controls. The following ERP components were examined: P1, N1, MMN, P2, early-P3 and late-P3. We used an auditory three-stimulus oddball paradigm, with standard (60%), target (20%) and distractor (20%) stimuli. FEP patients showed significantly lower amplitudes of P2, early-P3 and late-P3 components. FEP patients also showed significant deficits in all the MCCB cognitive domains. Finally, correlational analyses found strong associations between amplitudes of P2, early-P3 and late-P3 components and MCCB tests for attention and speed of processing. These findings indicate that deficits in late auditory ERP components are present in FEP, whereas early components are preserved. These reductions in late ERP components were related to attentional deficits in FEP as assessed by MCCB. These findings indicate that MCCB is a valid battery for studying cognitive impairments in the initial stages of schizophrenia, and highlight the utility of converging neurophysiological and neuropsychological measures to examine attentional impairments in schizophrenia.